- Title
- H-bond network, interfacial tension and chain melting temperature govern phospholipid self-assembly in ionic liquids.
- Creator
- Salvati Manni, Livia; Fong, Wye-Khay; Wood, Kathleen; Kirby, Nigel; Seibt, Susanne; Atkin, Rob; Warr, Gregory G.
- Relation
- ARC.DP200102248 http://purl.org/au-research/grants/arc/DP200102248
- Relation
- Journal of Colloid And Interface Science Vol. 657, p. 320-326
- Publisher Link
- http://dx.doi.org/10.1016/j.jcis.2023.11.158
- Publisher
- Elsevier
- Resource Type
- journal article
- Date
- 2024
- Description
- Hypothesis: The self-assembly structures and phase behaviour of phospholipids in protic ionic liquids (ILs) depend on intermolecular forces that can be controlled through changes in the size, polarity, and H-bond capacity of the solvent. Experiments: The structure and temperature stability of the self-assembled phases formed by four phospholipids in three ILs was determined by a combination of small- and wide-angle X-ray scattering (SAXS and WAXS) and small-angle neutron scattering (SANS). The phospholipids have identical phosphocholine head groups but different alkyl tail lengths and saturations (DOPC, POPC, DPPC and DSPC), while the ILs' amphiphilicity, H-bond network density and polarity are varied between propylammonium nitrate (PAN) to ethylammonium nitrate (EAN) to ethanolammonium nitrate (EtAN). Findings: The observed structures and phase behaviour of the lipids becomes more surfactant-like with decreasing average solvent polarity, H-bond network density and surface tension. In PAN, all the investigated phospholipids behave like surfactants in water. In EAN they exhibit anomalous phase sequences and unexpected transitions as a function of temperature, while EtAN supports structures that share characteristics with water and EAN. Structures formed are also sensitive to proximity to the lipid chain melting temperature.
- Subject
- iIonic liquids; lipid self-assembly; phospholipids; small angle neutron scattering; small angle X-ray scattering
- Identifier
- http://hdl.handle.net/1959.13/1500744
- Identifier
- uon:55005
- Identifier
- ISSN:0029-7971
- Rights
- © 2023 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- Language
- eng
- Full Text
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